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The relationship between Actigall, Cushing’s dog

By Tess Thompson

Hyperadrenocorticism in a dog is a potentially fatal disorder caused by adrenal dysfunction. This malfunction
leads to an excess production of a hormone called cortisone. Commonly known as Cushing’s disease, it
remains one of the most dreaded of all canine diseases.

Cushing’s disease in dogs causes a marked suppression in the immune system. This leads to multiple infections.
To escape elimination by the immune system, bacteria often find a safe haven in the gall bladder.

Cushing’s disease can make it easier for the bacteria to accumulate in the gall bladder
and the liver. This can cause conditions like liver dysfunction or hepatitis. Treatment
of such a condition can involve a lengthy regimen of preventive and remedial measures.

If your dog has Cushing’s disease, make sure that his liver and gall bladder are kept
clean and free of toxins. This can be done by understanding the manner in which the
liver functions.

The liver is the organ that is the first to come in contact with toxins after food is
processed by the digestive system. This is true for the human body system as well as
for your pet. Since the liver is a fairly large organ, minor damage is not easily noticed.

The liver secretes an alkaline, green fluid called bile. This fluid is stored in the gall
bladder between meals. During the eating process, bile is squirted through the bile duct
into the small intestines. The bile produced by the liver acts like a cleansing agent and helps in faster enzyme
action by increasing the surface area of consumed fat. The passage that connects the liver, gall bladder, and
small intestines is also a convenient passage for bacteria to travel.

Bile is mainly constituted of cholesterol derivatives called bile acids. After the bile enables the process of
digestion, part of the bile acids gets reabsorbed by the liver. The remainder passes
through the intestines and is ejected in feces.

An unhealthy liver can lead to many abnormal conditions. The cholesterol in bile can
occasionally accumulate into a compact mass forming gallstones. Low production of
bile results in indigestion of fats. This leads to further movement of toxins down the
intestines. Since almost all fats are absorbed in the small intestine, the bacterial
organisms in the large intestines are incapable of processing food after a certain time.

To be able to identify a liver disorder, look for external symptoms like increased
lethargy, loss of appetite, and diarrhea in your dog.

Some bile acids are toxic in nature. Although the bile acids produced by the liver of a
dog or a cat are less toxic than those in human bile, the intestinal bacteria in your dog
can potentially turn non-toxic bile acids into toxic ones. You can use certain artificial
bile acids like Ursodeoxycholic (trade name Actigall) to treat liver dysfunction in your dog. Actigall is a
recommended in conditions of low bile production. Actigall can also help to improve liver functioning and
protect the liver from becoming infected.
Adrenal Health